Prof. Francesco Secci, Università degli Studi di Cagliari
EMAIL: fsecci@unica.it
October 1– October 25, 2024
18 h, 3 CFU
Enantioselective transition metal catalysis is an area very much at the forefront of contemporary synthetic research. The development of processes that enable the efficient synthesis of enantiopure compounds is of unquestionable importance to chemists working within the many diverse fields of the central science. Traditional approaches to solving this challenge have typically relied on leveraging repulsive steric interactions between chiral ligands and substrates in order to raise the energy of one of the diastereomeric transition states over the other. This course will examine and purpose a series of synthetic tools and alternative tactics in which a set of classical and novel noncovalent interactions operating between transition metal ligands and substrates are used to control enantioselectivity. A purely theoretical part will be followed by a session dedicated to problem solving applied to the synthesis of complex molecules and the multistep synthesis of biologically active molecules. In this part, the development of ad hoc synthetic methodologies and the rational study for the design of new organometallic catalysts will be emphasized.